| Buildings of Local Significance |
Address |
| Academie Brochu | 29 Pine St. |
| Alden, William E., House | 428 Hamilton St. |
| Alden--Delahanty Block | 858 Main St. |
| Ammidown--Harding Farmhouse | 83 Lebanon Hill Rd. |
| Ashland Mill Tenement | 141--145 Ashland Ave. |
| Bacon--Morse Historic District | N. Woodstock Rd. at Tipton Rock Rd. |
| Beechwood | 495 Main St. |
| Boyer, Alexis, House | 306 Hamilton |
| Building at 25--27 River Street | 25--27 River St. |
| Building at 29--31 River Street | 29-31 River St. |
| Building at 38--42 Worcester Street | 38--42 Worcester St. |
| Building at 52 Main Street | 52 Main St. |
| Central Mills Historic District | Roughly bounded by Quinebaug River, North St., and Central St. |
| Centre Village Historic District | Along Main St. |
| Chamberlain--Bordeau House | 718 Main St. |
| Chapin Block | 208--222 Hamilton |
| Cheney, Alpha M., House | 61 Chestnut St. |
| Cheney, J. M., Rental House | 32 Edwards St. |
| Clarke--Glover Farmhouse | 201 South St. |
| Cliff Cottage | 787 Mill St. |
| Cole, E. Merritt, House | 386 Main St. |
| Comins--Wall House | 42 Hamilton St. |
| Congregational Church, Southbridge, Massachusetts | 61 Elm St. |
| Cummings, E. B., House | 52 Marcy St. |
| Dani and Soldani Cabinet Makers and Wood Workers Factory | 484 Worcester St. |
| Dennison School House | Dennison Ln. |
| Dresser, Sylvester, House | 29 Summer St. |
| Dunbar--Vinton House | Hook and Hamilton Sts. |
| Durfee, Henry E., Farmhouse | 281 Eastford Rd. |
| Elm Street Fire House | 24 Elm St. |
| Evangelical Free Church | Hamilton St. |
| Gleason, James, Cottage | 31 Sayles St. |
| Globe Village Fire House | West St. at Main St. |
| Glover Street Historic District | Glover St. between High and Poplar Sts. |
| Hamilton Mill--West Street Factory Housing | 45 West St. |
| Hamilton Mill Brick House | 16 High St. |
| Hamilton Millwright--Agent's House | 757--761 Main St. |
| Hamilton Woolen Company Historic District | Roughly bounded by McKinstry Brook, Quinebaug River, and Mill St. |
| Harrington, Theodore, House | 77 Hamilton St. |
| Hartwell, George H., House | 105 Hamilton St. |
| Hartwell, Samuel C., House | 79 Elm St. |
| High--School Streets Historic District | High St. at School St. |
| Hodgson, William, Two-Family House | 103--105 Sayles St. |
| House at 18 Walnut Street | 18 Walnut St. |
| House at 34 Benefit Street | 34 Benefit St. |
| House at 3 Dean Street | 3 Dean St. |
| House at 59--63 Crystal Street | 59--63 Crystal St. |
| House at 64 Main Street | 64 Main St. |
| House at 70--72 Main Street | 70--72 Main St. |
| House at 91 Coombs Street | 91 Coombs St. |
| Judson--Litchfield House | 313 South St. |
| Kinney, A., House | 42 Edwards St. |
| LaCroix--Mosher House | 56 Everett St. |
| LaRochelle, Napoleon, Two-Family House | 30 Pine St. |
| Maple Street Historic District, Southbridge, Massachusetts | Maple St. |
| Marcy, Mrs. R., House | 64 South St. |
| McKinstry, William, Farmhouse | 361 Pleasant St. |
| McKinstry, William, Jr., House | 915 W. Main St. |
| Morse, H., House | 230 South St. |
| New York, New Haven & Hartford Passenger Depot | Depot St. |
| Notre Dame Catholic Church | Main St. at Marcy St. |
| Oakes, J. J., House | 14 South St. |
| Phillips, E. M., House | 35 Dresser St. |
| Plimpton, Simon, Farmhouse | 561 South St. |
| Richard, Stephen, House | 239--241 Elm St. |
| Sacred Heart Church Historic District | Charlton St. |
| Smith--Lyon Farmhouse | 400 N. Woodstock Rd. |
| Southbridge Town Hall | 41 Elm St. |
| St. George's Greek Orthodox Church | 55 North St. |
| St. Peter's Roman Catholic Church--St. Mary's School | Hamilton and Pine Sts. |
| Stone, Lorenzo R., House | 218 South St. |
| Sumner, George, House | 32 Paige Hill Rd. |
| Tapin, Eugene, House | 215 Lebanon Hill Rd. |
| Tiffany--Leonard House | 25 Elm St. |
| Twinehurst American Optical Company Neighborhood | Winchurst St. |
| Upper Chapin Street Historic District | Chapin St. at Forest Ave. |
| Vinton--Boardman Farmhouse | 93 Torrey Rd. |
| Vinton--Torrey House | 5 Torrey Rd. |
| Wells, George B. and Ruth D., House | Durfee Rd. |
| Wells, H. C., Double House | 28--30 Dresser St. |
| Wells, John M., House | 491 Eastford Rd. |
| Wheeler, Albert H., House | 219 South St. |
| Windsor Court Historic District | Windsor Ct. at North St. |
